This study examines the impact of vineyard desiccant sprays on grape ripening and wine quality in Cabernet Franc. A block of Cabernet Franc was divided so that part of the block was backpack-sprayed with a desiccant spray (2% solution of methyl esters of fatty acids in 2% solution of potassium carbonate in water) provided by Bruce Zoecklein. The spray treatment occurred when the grapes had reached approximately 19 Brix (September 22, 2017) and clusters were coated until dripping with spray. Grapes were harvested on September 28 and were processed identically. Wines were pressed after 11 days of maceration. Cluster weight, total anthocyanins, and tannin were decreased in sprayed fruit. Brix was increased and acidity was decreased in sprayed fruit as well. Alcohol and potassium were higher in the sprayed wine, and acidity was lowered. Color, tannin, and polymeric anthocyanin were also higher in the sprayed wine, in spite of opposite trends being seen in this regard with the grapes. Overall, these wines were found to be significantly different. There was a tendency for the desiccated wine to have higher Body. Desiccated wines had a slight tendency for higher Acidity and Astringency, and lower Fruit Intensity. However, more sensory studies are needed to confirm these trends. There may have been a very slight preference for the non-desiccated wine. In the future, more studies should be performed on fruit desiccation, as it has potential to be a useful tool in Virginia grape growing. These studies should include the timing of desiccation sprays before harvest.