This study examines the impact of a desiccation spray on the chemical and sensory profiles of Chambourcin grapes and wine. One block of Chambourcin was divided so that one section of fruit was sprayed with a potassium bicarbonate desiccant, and another section was not sprayed. The desiccated fruit was sprayed at the beginning of veraison and then weekly for a total of four sprays over four weeks. The fruit was harvested and processed on the same day, and all treatments between the fruit were identical. The desiccation treatment slightly concentrated berry components, although not many differences were found in wine. The desiccation treatment, however, lowered the color intensity and slightly lowered the tannin and anthocyanin content in the wine. Other parameters were not greatly affected. At one tasting, the wines were found to be significantly different (p<0.05), and in general there was a preference for the wine made without desiccation. At another tasting, there was no significant difference between wines, and no major preference trends. More studies on desiccation across vintages would be beneficial to further elucidate the impact of these treatments in Virginia.